If you’re old enough to remember ‘flip phones,’ then you might remember the first time phones had cameras. Fast forward 10-20 or so odd years – now, phone cameras have front and back lenses with incredible resolution and the latest image processing technology. Now, imagine taking a picture of a dog with a flip phone from the early 2000s and with another phone released in 2023. The dog remains the same, but the image itself vastly differs. This is what is known as domain shift in medical imaging technology; the equipment and user used to capture the same object differs. Specifically in medicine, hospitals use different brands and specifications of equipment acquired from various vendors, which can depend on their resources and budget.